Post Doctoral Scholar

Postdoctoral Fellow in Cancer Biology, CRISPR-Cas9 Screening and Epigenetics

Description:We are seeking highly motivated and enthusiastic Ph.D. or MD scientists to join our group as postdoctoral research fellows.

We are now accepting applications for a postdoctoral fellow position in the laboratory of Dr. Triparna Sen at Department of Internal Medicine, The Ohio State University.

Dr. Sen is a Professor and her lab aims to achieve a systematic and comprehensive understanding of the mechanisms of phenotypic plasticity, therapeutic resistance, and immune escape mechanisms in human malignancies with a primary focus on lung cancer. The lab has established the use of multiple high-throughput screening technologies, genomics, proteomics, epigenetics, clinical samples, and animal models to accomplish these goals, which will promise to provide critical insights into the molecular circuitry that drives these lung cancers and, consequently, results in the development of novel therapeutic strategies for the clinically relevant molecular subsets of lung cancer.

The applicant would lead functional genomic screening efforts applying CRISPR base editing and CRISPRa/i screening to characterize synthetic lethal and resistance mechanisms underlying disease development, genetic and epigenetic biomarkers for lung cancer precision medicine, and signal transduction changes during disease progression. A strong background in genetics and genomics is preferred.

Postdoctoral research will be performed in a highly interdisciplinary and collaborative environment with world-class experts and advanced technologies and facilities, which provide unique and ideal career development opportunities for postdocs. The individual will engage in experiments involvingCRISPRlibrary screening, next-generation sequencing, gene expression (RNA-seq), molecular cloning, and eventually exploiting targeted therapy for human thoracic malignancies.

Job Responsibilities:

• Plans and directs experiments
• Identifies original research projects, experiments, and research directions
• Collects, evaluates, and interprets research data to accomplish research objectives.
• Independently prepares abstracts, research reports, and manuscripts for publication
• Participates in grant preparation and submissions
• May supervise graduate students and research technologists
• Maintains a safe laboratory environment and ensures compliance with governmental and University policies, procedures, rules, and regulations.
• Performs other job-related assignments as assigned.

Qualifications

A PhD or MD/PhD, within the last three years with extensive experience cell/molecular biology or immunology, and experience in animal models. Excellent knowledge and expertise in cancer cell culture, CRISPR-mediated gene silencing approaches Western blotting, qRT-PCR, immunoprecipitation, high-quality flow cytometry-based assays, and molecular cloning. Experience in RNA-seq and next-generation sequencing data analysis is desirable. A proven academic publication track record, including first-authored publications at high-profile journals.

Requires successful completion of a background check. The selected candidate may be requested to complete a pre-employment physical including a drug screen.

The Ohio State University is a dynamic community of diverse resources, where opportunity thrives and where individuals transform themselves and the world. The Ohio State University is one of the nations largest and most comprehensive public universities and a top employer in Ohio.

As one of only 57 designated comprehensive cancer centers in the nation, The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute is dedicated to the creation of knowledge in laboratory, clinical and population-based cancer research. We apply those discoveries to develop more effective approaches to cancer prevention, diagnosis, and therapies providing tomorrows standard of care today. A Cancer-Free World Begins Here.

The OSUCCC James is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nations largest public universities. is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nations largest public universities.