New

Software Principal Engineer

Vertex Pharmaceuticals Incorporated
paid time off, 401(k)
United States, Massachusetts, Boston
50 Northern Avenue (Show on map)
Jan 07, 2026
Job Description Employer: Vertex Pharmaceuticals Incorporated JOB TITLE: Software Principal Engineer LOCATION: 50 Northern Ave., Boston, Massachusetts, 02210 OPENINGS: 1 DUTIES: Handle complex engineering tasks and project initiatives. Provide technical guidance and mentorship to junior engineers. Lead technical reviews and ensure adherence to best practices. Collaborate on the development of innovative software solutions. Support the Associate Director or Director with strategic technical insights. Lead the design and development of complex software systems within the scientific space. Collaborate with cross-functional teams to define project requirements and deliverables of custom applications. Conduct code reviews to ensure high-quality code and adherence to best practices. Identify and resolve performance and scalability issues, using AWS and Cloud Computing. Develop and maintain technical documentation. Ensure software security and compliance with industry standards. Drive continuous improvement in software development processes using Agile methodologies. Participate in strategic planning and decision-making for technology initiatives. Telecommuting permitted up to 40%. REQUIREMENTS: Employer will accept a Bachelor's degree in Technology, Computer Science, Software Engineering, or a related field and 6 years of experience in the job offered or in a Software Principal Engineer-related occupation. Position requires 72 months of experience in the following: Exceptional problem-solving and technical skills in software engineering. Ability to mentor and guide junior engineers. Strong expertise in software architecture and system design. Proficiency in leading technical initiatives and innovation. Support and development of java applications. Support and development of web applications. Progression and assistance of existing applications using Flask and Django and development and building and aiding of new web applications using FastAPI. Knowledge of modern JavaScript frameworks including Angular and VueJS to support and develop existing and new application frameworks for frontend and UI development. Knowledge of Cloud computing to transition systems from in house serves to Cloud-based solutions to scale infrastructure and development. Experience with Microsoft Azure or Amazon Web Services (AWS) Cloud infrastructure including Fargate, EC2 and S3 to maintain scale and development of new services. Telecommuting permitted up to 40%. Rate of Pay: $178132.00 - $216000.00 CONTACT: Send Resume to futuretalent@vrtx.com. Reference 12140.605. EOE. #LI-DNI Pay Range: $0 - $0 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Remote-Eligible Flex Eligibility Status: In this Remote-Eligible role, you can choose to be designated as: 1. Remote: work remotely five days per week and come into the office on occasion - you're always welcome on-site; or select 2. Hybrid: work remotely up to two days per week; or select 3. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Remote Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com