Executive Director, Head of Medical Excellence, Operations, and Planning

Reporting to the SVP, Head of Medical Affairs, the Executive Director, Head of Medical Excellence, Operations, and Planning is a senior operational and strategic leader within Global Medical Affairs and a key member of the Medical Affairs Leadership Team (MALT). This leader holds primary accountability for defining and driving the Medical Affairs Operations and Excellence strategy globally. They will oversee the teams, systems, analytic frameworks, and governance that enable data driven decision making across Medical Affairs-ensuring that insights, performance analytics, technology platforms, and operational capabilities are aligned with enterprise objectives. The Executive Director plays a central role in shaping Medical Affairs' operating model, standardizing processes globally, enabling digital transformation, and ensuring high quality execution across regions and therapeutic areas.

This position will be located at Alnylam Headquarters in Cambridge, MA

Key Responsibilities

Strategic & Operational Leadership

*Serve as a senior advisor and strategic thought partner to the SVP, Head of Medical Affairs, providing operational leadership and strategic guidance with a strong focus on data driven decision making and analytic insights across the Global Medical Affairs organization.

*Lead the development and execution of the Medical Affairs Operations and Excellence strategy, ensuring processes, systems, and resources support global consistency, compliance, and scalable growth.

*Direct, standardize, and optimize Medical Affairs processes through governance, analytics, and operational best practices to improve efficiency and reduce risk.

Functional Leadership & Cross Functional Influence

*Oversee teams responsible for operational support of key Medical Affairs initiatives, including launch readiness, advisory boards, medical roundtables, scientific exchange programs, and medical dashboards that track plan execution and outcomes.

*Build and maintain strong collaborative relationships across Medical Affairs leadership and relevant cross functional partners-Commercial, Clinical Development, Regulatory, Finance, Patient Advocacy-to ensure alignment, consistency, and effective planning across regions and therapeutic areas.

*Coordinate cross functional annual and long range planning processes, meeting cadences, communications, and budget oversight on behalf of Medical Affairs leadership.

Medical Excellence, Governance & Capabilities

*Lead the development and continuous improvement of guidance documents, including policies, operating guidelines, SOPs, and training materials that elevate Medical Affairs operational rigor and excellence.

*Partner with Medical Affairs and IT leaders to define and implement new medical technology, data, and analytic solutions to support strategic decision making and performance measurement. making and performance measurement.

*Identify, evaluate, and embed best practices across geographies, ensuring that learnings and innovations are shared, adopted, and operationalized globally.

Leadership & Talent Development

*Provide strong leadership to direct reports and cross functional teams, cultivating a culture of excellence, accountability, and continuous improvement.

*Actively develop talent by coaching, mentoring, and building capabilities within the organization, serving as a player coach who supports execution while enabling team growth.

*Represent Medical Affairs Operations and Excellence in leadership forums, contributing proactively to functional planning and organizational effectiveness initiatives.

Qualifications

*Bachelor's degree in life sciences required; MBA, management consulting background, or Medical Excellence experience strongly preferred.

*Minimum 15 years of experience in the pharmaceutical or biotechnology industry, with significant experience in Medical Affairs, operations, or related strategic functions.

*At least 5 years of people leadership experience, with a demonstrated ability to develop and lead high performing teams.

*Deep knowledge of the biopharmaceutical industry, including medical governance, compliance, regulations, and industry standards.

*Demonstrated ability to influence at senior levels and collaborate effectively across global and regional matrixed organizations.

*Exceptional communication, analytical, and planning skills, with the ability to translate strategic objectives into operational frameworks.

*Ability to balance near term operational execution with long term strategic planning, connecting daily activities to broader business priorities and industry trends.

*Proven track record of leading cross functional teams to deliver outstanding business outcomes.

*Thrives in a fast paced, entrepreneurial biotech environment and embraces Alnylam's culture of science, passion, and urgency.

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U.S. Pay Range

$267,800.00 - $362,300.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.