Clinical Research Coordinator I

This Clinical Research Coordinator I role is embedded in Dr. Vamsi Mootha's laboratory-with Dr. Mootha serving as the lead PI of the Mitochondrial Medicine Unit-and operates under the clinical direction of Dr. Walker (Neurology) and Dr. Sharma (Medicine) to advance translational research in mitochondrial disease. The position integrates humansubject activities with benchbased methods (e.g., clinical procedures and core molecular techniques).

In addition to the baseline CRC I responsibilities, the position requires laboratory competencies central to mitochondrial research, including human biospecimen processing and handling, basic cell culture, and molecular assays such as qPCR and ELISA, enabling direct linkage between clinical phenotypes and benchbased analyses.

The role also entails management of a diseasespecific research registry and biorepository-with responsibilities for aliquoting, coding, longterm storage, and compliant shipping-to ensure highquality, retrievable samples for current and future studies.

Programmatic and collaborative expectations include presenting progress in weekly meetings, assisting with conferences such as the MitoCase seminar series, and providing administrative support for educational initiatives of the MGH Mitochondrial Medicine Unit, thereby extending impact beyond individual studies.

The coordinator will partner with national patientadvocacy organizations (e.g., UMDF, MitoAction, FARA) and coordinate across multiple institutions, activities that are essential to advancing research in rare mitochondrial disorders.

Finally, the position provides regulatory support at a level commensurate with complex raredisease research, including QA/QC, proofreading of regulatory and scholarly documents, and assistance with submissions up to and including Expanded Access/Compassionate Use IND protocols.

Given the highly specialized nature of the work, it is imperative that candidates possess direct and demonstrable experience across all of the above domains-including mitochondrial or related molecular biology techniques, biospecimen handling, biorepository operations, and raredisease research coordination-in order to successfully fulfill the responsibilities of this role.

Additionally, preferred qualifications include a bachelor's degree with 3-12 months of prior mitochondrial molecular biology or similar bench research experience, as well as prior recordkeeping, archival, or patientinteraction experience, which are necessary to perform the unique research, regulatory, and collaborative functions required.